General Information

  • ID:  hor001243
  • Uniprot ID:  G5EEC2
  • Protein name:  FLP-7
  • Gene name:  flp-7
  • Organism:  Caenorhabditis elegans
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Expressed in eggs, all larval stages and in adult . |Expressed in the ASI sensory neurons, the ALA interneuron and the AVG interneuron from where secretion occurs. Expression in the ASI neurons is necessary and sufficient to maintain serotonin-induced fat
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0071855 neuropeptide receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0019932 obsolete second-messenger-mediated signaling; GO:0040013 negative regulation of locomotion
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  TPMQRSSMVRFG
  • Length:  12(52-63)
  • Propeptide:  MLGSRFLLLALGLLVLVLAEESAEQQVQEPTELEKSGEQLSEEDLIDEQKRTPMQRSSMVRFGRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMERSAMVRFGRSPMDRSKMVRFGRSSIDRASMVRLGKRTPMQRSSMVRFGKRSMEFEMQSNEKNIEDSE
  • Signal peptide:  MLGSRFLLLALGLLVLVLA
  • Modification:  T11 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  FMRFamide-like neuropeptides (PubMed:16377032, PubMed:28128367). Stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss (PubMed:33078707). Together with
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-G5EEC2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001243_AF2.pdbhor001243_ESM.pdb

Physical Information

Mass: 159301 Formula: C58H97N19O17S2
Absent amino acids: ACDEHIKLNWY Common amino acids: MRS
pI: 12.5 Basic residues: 2
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -50 Boman Index: -3209
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 24.17
Instability Index: 4926.67 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  17564681
  • Title:  Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.